1/12/2024 0 Comments Fly brain dopaminergic neurons![]() New tools and platforms are needed in the discovery arena to overcome these limitations. The majority of positive hits identified through these types of in vitro screens, unfortunately, are found to be ineffective and/or toxic in subsequent validation experiments in whole-animal models. In the discovery process for therapeutics, traditional approaches employ high-throughput screening for small molecules that is based primarily on in vitro cell culture, enzymatic assays, or receptor binding assays. ![]() melanogaster, and nearly 75% of human disease-causing genes are believed to have a functional homolog in the fly. Many basic biological, physiological, and neurological properties are conserved between mammals and D. The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases.
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